{"id":876,"date":"2022-04-27T17:13:47","date_gmt":"2022-04-27T15:13:47","guid":{"rendered":"https:\/\/www.lactolerance.fr\/blog\/?p=876"},"modified":"2025-07-24T15:22:57","modified_gmt":"2025-07-24T13:22:57","slug":"lactase-2","status":"publish","type":"post","link":"https:\/\/www.lactolerance.fr\/blog\/en\/lactase-2\/","title":{"rendered":"Lactase: the enzyme that digests lactose"},"content":{"rendered":"<h2><\/h2>\n<h2 class=\"p1\" style=\"text-align: justify;\"><b>What is lactase?<\/b><\/h2>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\">Lactase or \"lactase-phloridzin hydrolase\" is <strong>an enzyme that belongs to the family of Beta Galactosidases\u00a0<\/strong>A group of enzymes whose main function is to break down complex sugars into simple sugars.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\"><strong>Lactase is composed of more than 1900 amino acids<\/strong>It is excreted by the intestinal cells (enterocytes) into the digestive tract and its main role is to break down the <a href=\"https:\/\/www.lactolerance.fr\/blog\/en\/le-lactose\/\" target=\"_blank\" rel=\"noopener\">lactose<\/a>a type of disaccharide, into two simple sugars: glucose and galactose ; <a href=\"https:\/\/www.lactolerance.fr\/fr\/content\/51-lactose\" data-internallinksmanager029f6b8e52c=\"16\" title=\"lactose\">lactose<\/a> is often called milk sugar because it is found mainly in cow's milk and dairy products (cheese, butter and yoghurt), and has the chemical formula C12 H22 O11.<\/span><\/p>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\">This enzyme has <strong>an activity that varies over the course of a person's life<\/strong>In the first half of life, it will be at its peak at birth and then slowly decrease during childhood as milk consumption decreases. Finally, it disappears almost completely in adults, although it remains active in a few people. <span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<h2 class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\"><b>Lactose intolerance<\/b><\/span><\/h2>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\">Lactose intolerance is an abdominal syndrome marked by <strong>the appearance of acute abdominal pain, bloating and <a href=\"https:\/\/www.lactolerance.fr\/blog\/en\/diarrhea\/\" data-wpil-monitor-id=\"62\">diarrhoea<\/a> sometimes vomiting<\/strong> especially in children, 30 minutes to 2 hours after ingesting dairy products because of their high lactose content. The intensity of symptoms depends on the quantity ingested and the degree of lactase deficiency. Intolerance to <a href=\"https:\/\/www.lactolerance.fr\/blog\/en\/symptoms-of-lactose-intolerance\/\" data-wpil-monitor-id=\"63\">lactose may have no symptoms<\/a> in certain subjects.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<h2 class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\"><b>Causes of lactose intolerance<\/b><\/span><\/h2>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\">Lactase deficiency is linked to 3 main causes:<\/span><\/p>\n<ul class=\"ul1\" style=\"text-align: justify;\">\n<li class=\"li1\"><strong><span class=\"s1\">Partial and temporary deficit<\/span><\/strong><span class=\"s2\">\u00a0Gastroenteritis: often encountered in cases of intestinal mucosal damage such as viral and bacterial gastroenteritis, inflammatory bowel disease (Crohn's disease), malabsorption defects (coeliac disease) and irritable bowel syndrome.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/li>\n<li class=\"li1\"><strong><span class=\"s1\">Total (congenital) deficiency\u00a0<\/span><\/strong><span class=\"s1\">:<\/span><span class=\"s2\"> it begins at birth, the enterocytes do not have the capacity to synthesise lactase, the cause is genetic: genetic mutation of the LCT gene on chromosome 2 or transcription defect of the LCT gene, autosomal recessive mechanism.<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><strong>Ethnic and dietary deficits\u00a0<\/strong>:<\/span><span class=\"s2\"> In the majority of Asians and in some countries of equatorial Africa and South America, milk consumption is not part of their dietary habits, which hinders the excretion of lactase by the enterocytes. The severity of this deficiency is often remarkable in infants because breast or formula milk is the only source of nutrition for them before dietary diversification and the introduction of gluten-based foods from 6<\/span><span class=\"s4\"><sup>\u00e8me<\/sup><\/span><span class=\"s2\"> In the first few months of life, heavy diarrhoea can cause dehydration in the short term and even undernutrition in the medium term. These complications are dangerous and should be managed as soon as possible.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/li>\n<\/ul>\n<h2 class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\"><b>How is lactose intolerance diagnosed?<\/b><\/span><\/h2>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\">To confirm the diagnosis of lactose intolerance, several tests can be done:<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<ul class=\"ul1\" style=\"text-align: justify;\">\n<li class=\"li1\"><strong><span class=\"s1\">Blood glucose measurement after lactose intake<\/span><\/strong><span class=\"s2\"><strong>\u00a0<\/strong>Lactose tolerance test: this is a simple and quick test, the blood sugar level is measured at least 4 times during 03 hours after the ingestion of lactose; if the synthesis of lactase is deficient, the blood sugar level will not rise because the lactose will not be broken down into glucose. For diabetics, this test is not reliable enough because they have already high blood sugar levels.<\/span><\/li>\n<li class=\"li1\"><strong><span class=\"s1\">Hydrogen breath test (BHT)<\/span><\/strong><span class=\"s2\"><strong>\u00a0<\/strong>lactose intolerance: this is the most commonly used test for the diagnosis of lactose intolerance, it is <b>reliable<\/b> and <b>very specific<\/b>\u00a0After ingesting 10 g of lactose, the undigested lactose undergoes fermentation in the intestine, which causes a hyperproduction of hydrogen that is eliminated by the lungs; the measurement of exhaled hydrogen (the hydrogen that exits the lungs through the nose or mouth) is done over 3 successive hours. The presence of a high concentration of hydrogen in the breath means that lactase synthesis is deficient as most of the lactose will have been digested by colonic bacteria.<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><strong>Intestinal biopsy\u00a0<\/strong>:<\/span><span class=\"s2\"> In some cases, intestinal biopsy is necessary to test the response of the enterocytes to lactose by measuring lactase enzyme activity, if the lactose does not break down, the diagnosis of lactose intolerance will be made.<\/span><\/li>\n<\/ul>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s2\">This test is invasive and is only performed if the <a href=\"https:\/\/www.lactolerance.fr\/blog\/en\/breath-hydrogen-test\/\" data-wpil-monitor-id=\"64\">breath test<\/a> with hydrogen does not give satisfactory results.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<h2 class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\"><b>Solutions and treatment<\/b><\/span><\/h2>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\">To reduce the symptoms of lactose intolerance, <strong>regular milk should be substituted with lactose-free milk<\/strong>especially for children and infants. Consumption of lactose-free dairy products is also recommended for adults; yoghurts enriched with bacteria that produce lactase (<em>Lactobacillus acidophilus, Bifidobacterium, Streptococcus thermophilus<\/em>) are useful for improving lactose digestion.<\/span><\/p>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\"><strong>LACTOLERANCE lactase-based food supplements<\/strong>These products help to reduce the digestive problems associated with lactose intolerance.<\/span><\/p>\n<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s2\">People who suffer from this syndrome should <strong>limit their consumption of dairy products<\/strong>\u00a0provided they consume other sources of calcium and vitamin D such as fruit, vegetables, oilseeds and fish, to prevent bone demineralisation and the risk of fractures.<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p>\n<p><a href=\"https:\/\/www.lactolerance.fr\/fr\/nos-complements-alimentaires\/134-pack-decouverte-protection-24h-134.html\"><img decoding=\"async\" class=\"alignnone wp-image-1108 size-full\" src=\"https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte.jpg\" alt=\"Image redirecting to the lactor\u00e9lance 1day pack and 9000 pill dispenser product sheet\" width=\"100%\" height=\"NaN\" srcset=\"https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte.jpg 2400w, https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte-400x133.jpg 400w, https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte-800x267.jpg 800w, https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte-768x256.jpg 768w, https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte-1536x512.jpg 1536w, https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte-2048x683.jpg 2048w, https:\/\/www.lactolerance.fr\/blog\/wp-content\/uploads\/2022\/12\/Blog-bas-de-page-FR-NOUVEAU-PACK-Decouverte-18x6.jpg 18w\" sizes=\"(max-width: 2400px) 100vw, 2400px\" \/><\/a><\/p>\n<div class=\"su-divider su-divider-style-default\" style=\"margin:15px 0;border-width:3px;border-color:#e50953\"><a href=\"#\" style=\"color:#e50953\">Go to top<\/a><\/div>\n<style>\n.faq-custom h4 {\n  background-color: #2b1112;\n  color: #fff8f2;\n  padding: 10px;\n  border-radius: 4px;\n  margin-top: 1em;\n}\n<\/style>\n<div class=\"rank-math-schema-faq faq-custom\" itemscope itemtype=\"https:\/\/schema.org\/FAQPage\">\n<div itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\">\n<h4 itemprop=\"name\">What is lactase and what does it do?<\/h4>\n<div itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\">\n<p itemprop=\"text\">Lactase is an enzyme produced in the small intestine, essential for digesting lactose: it splits it into glucose and galactose, two absorbable sugars.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\">\n<h4 itemprop=\"name\">Why do some people lack lactase?<\/h4>\n<div itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\">\n<p itemprop=\"text\">Lactase deficiency can be genetic (natural decline after childhood) or acquired following an intestinal disease. Certain populations are more affected, depending on their genetic predisposition.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\">\n<h4 itemprop=\"name\">What are the symptoms of lactase deficiency?<\/h4>\n<div itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\">\n<p itemprop=\"text\">Lactase deficiency leads to poor digestion of lactose and causes bloating, diarrhoea, gas and abdominal pain after eating dairy products.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\">\n<h4 itemprop=\"name\">How is lactase deficiency diagnosed?<\/h4>\n<div itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\">\n<p itemprop=\"text\">Diagnosis can be made via a hydrogen breath test, a genetic test, or lactose elimination supervised by a healthcare professional.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div itemscope itemprop=\"mainEntity\" itemtype=\"https:\/\/schema.org\/Question\">\n<h4 itemprop=\"name\">What can be done about a lactase deficiency on a daily basis?<\/h4>\n<div itemscope itemprop=\"acceptedAnswer\" itemtype=\"https:\/\/schema.org\/Answer\">\n<p itemprop=\"text\">You can adopt a low-lactose diet, choose fermented products, or take a lactase supplement such as LACTOLERANCE 1\/DAY, 4500, 9000 or ULTRA depending on your needs.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>What is lactase? Lactase or \"lactase-phloridzin hydrolase\" is an enzyme that belongs to the family of Beta galactosidases: it is a group of enzymes whose main function is to break down complex sugars into simple sugars.  Lactase is composed of more than 1900 amino acids and is excreted by the intestinal cells (enterocytes) in the bloodstream.<\/p>","protected":false},"author":4,"featured_media":3127,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"footnotes":""},"categories":[42],"tags":[],"class_list":["post-876","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-comprendre-son-intolerance-au-lactose"],"_links":{"self":[{"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/posts\/876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/comments?post=876"}],"version-history":[{"count":16,"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/posts\/876\/revisions"}],"predecessor-version":[{"id":3131,"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/posts\/876\/revisions\/3131"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/media\/3127"}],"wp:attachment":[{"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/media?parent=876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/categories?post=876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lactolerance.fr\/blog\/en\/wp-json\/wp\/v2\/tags?post=876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}